Created by colleagues to save time through knowledge sharing. Join us now!

  • Create your personal profile
  • Easily share you publications, video's, case-studies, blogs, presentations, posters, or other information
  • Your publications will be connected directly to PubMed
  • Join or start a discussion and invite colleagues
  • Find yourself in a secured online environment

Latest News

Clonal evolution leading to ibrutinib resistance in CLL

News 2 days ago

Histologic transformation or acquired mutations in BTK and PLCG2 can cause disease progression in patients with chronic lymphocytic leukemia (CLL) treated with ibrutinib. The rate of resistance and clonal composition of progressive disease are incompletely characterized.  A recent publication in […]

Strong control on the clonal expansion of CLL

News 3 days ago

The data of a preclinical study, published in Leukemia, demonstrate that the strong control by miR-15a and miR-16-1 on the clonal expansion of chronic lymphocytic leukemia (CLL) is exerted also at the level of full-blown leukemia. These findings provide indications […]

HSCT after PD-1 blockade is feasible in lymphoma

News 5 days ago

After treatment with anti-PD-1 monoclonal antibodies, allogeneic hematopoietic stem cell transplant (HSCT) appears feasible in patients with relapsed/refractory lymphoma. This treatment results in a low relapse rate, but there may be an increased risk of early immune toxicity, which could […]

Cancer Genomics: Addressing treatment resistance in childhood ACL

News 1 month ago

In the third week of PLOS Medicine‘s ongoing special issue on cancer genomics, principal investigator Jules Meijerink of the Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands and colleagues seek to identify mechanisms underlying treatment resistance in children with […]